I ran in to the following problem in a SharePoint Server SP2 environment: The exception message was ‘The process cannot access the file ‘D:BlobCachefolder’ because it is being used by another process.’
After some troubleshooting and discussions with Microsoft I finally got confirmed that this is a known issue, not very frequent but still. This is caused when the worker process updates or deletes a cached file and a request comes simultaneously to the WFE server for a MOSS page that contains the cached item.
This is corrected in August Cumulative update even if it’s not specifically mentioned in the kb. http://support.microsoft.com/kb/973400/
Below you see how it was showned in my case.
Event Type: Error
Event Source: Office SharePoint Server
Event Category: Publishing Cache
Event ID: 5538
User: N/A
Description:
An error occured in the blob cache. The exception message was ‘The process cannot
access the file
‘D:BlobCachefolder’ because it is being used by another process.’